![]() However, DOX can also cause damage to normal body cells (Varela-López et al., Citation2019). ![]() In addition to this, it has also been proved to induce immunogenic cell death (ICD) in tumor cells (Li et al., Citation2021 Ren et al., Citation2021 Zhang et al., Citation2022). For example, doxorubicin (DOX), which is commonly used in clinic, has shown good therapeutic effect on breast cancer. At present, chemotherapy is still one of the common methods for breast cancer therapy in clinical (Palmeira et al., Citation2012). ![]() The incidence of breast cancer in Chinese women has been increasing rapidly and getting younger in the past two decades (Fischer et al., Citation2022). ![]() It also shows the ability of remove oxygen free radicals effectively to prevent the cardiotoxicity of DOX.īreast cancer, with the highest morbidity and mortality, is the second reason of cancer-related deaths among women worldwide (Koual et al., Citation2020). In conclusion, PEI-DOX/EGCG/FA can inhibit the expression of P-gp and reverse the MDR in tumor cells. The ability of EGCG to reduce DOX cardiotoxicity is confirmed by cardiotoxicity assay. Additionally, we investigate the anti-drug resistant mechanism by Western Blot. The MDR reversal and targeting ability of PEI-DOX/EGCG/FA is performed by cytotoxicity and in vivo anti-tumor activity on multidrug resistant MCF-7 cells (MCF-7/ADR). In addition, folic acid (FA) modified polyethylene glycol (PEG) (PEG-FA) is added to get the targeted system PEI-DOX/EGCG/FA. In this study, DOX is connected with low molecular weight polyethyleneimine (PEI) via hydrazone bond to get the pH-sensitive PEI-DOX, which is then combined with EGCG to prevent the cardiotoxicity of DOX and reverse the MDR of cancer cells. Meanwhile, EGCG can inhibit the expression of P-glycoprotein (P-gp) and reverse the MDR of tumor cells. Epigallocatechin gallate (EGCG), a natural antioxidant component, can effectively reduce the cardiotoxicity of DOX. ![]() Doxorubicin (DOX), a commonly used anti-cancer drug, is limited by its cardiotoxicity and multidrug resistance (MDR) of tumor cells. ![]()
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